En route to photoaffinity labeling of the bacterial lectin FimH

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En route to photoaffinity labeling of the bacterial lectin FimH

Mannose-specific adhesion of Escherichia coli bacteria to cell surfaces, the cause of various infections, is mediated by a fimbrial lectin, called FimH. X-ray studies have revealed a carbohydrate recognition domain (CRD) on FimH that can complex α-D-mannosides. However, as the precise nature of the ligand-receptor interactions in mannose-specific adhesion is not yet fully understood, it is of i...

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The mechanism of photoaffinity labeling.

Photoaffinity labeling is a recently introduced method for covalently binding chemical tags to the active sites of protein molecules, which is potentially capable of very great specificities of labeling. A labeling reagent is used that is converted by photolysis to an extremely reactive intermediate. According to the expected mechanism, the reagent molecules that are specifically and reversibly...

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Are D-manno-configured Amadori products ligands of the bacterial lectin FimH?

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ژورنال

عنوان ژورنال: Beilstein Journal of Organic Chemistry

سال: 2010

ISSN: 1860-5397

DOI: 10.3762/bjoc.6.91